CJC-1295 WITHOUT DACMOD GRF 1-29
Tetrasubstituted GHRH(1–29) amide — Modified GRF 1-29, without the Drug Affinity Complex.
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For laboratory research use only. Not for human or veterinary consumption, diagnostic or therapeutic use. Handle in accordance with institutional safety procedures.
Product Overview
Scientific profile
Modified GRF (1-29), commonly called CJC-1295 WITHOUT DAC, is a 29-residue C-terminally amidated analogue of the bioactive N-terminal fragment of growth-hormone-releasing hormone (GHRH). It does not carry the maleimidopropionyl-lysine "Drug Affinity Complex" used in CJC-1295 with DAC.
Research Background
Four amino-acid substitutions improve stability relative to sermorelin (GHRH 1–29): D-Ala2 resists DPP-4 cleavage, Gln8 prevents asparagine deamidation/rearrangement, Ala15 enhances receptor bioactivity and Leu27 removes an oxidation-prone methionine. The peptide is an agonist of the GHRH receptor on pituitary somatotrophs and is frequently studied alongside ghrelin-receptor agonists.
Areas of Investigation
- GHRH-receptor (GHRHR) signalling and cAMP-dependent GH release
- Peptide stabilisation strategies against DPP-4 and oxidation
- Synergy between GHRH analogues and GH secretagogues
- Pulsatile versus sustained GH-axis stimulation models
Analytical Profile
Purity by reverse-phase HPLC; identity confirmed by ESI-MS. Supplied as a lyophilized peptide.
Specifications
Chemical & physical data
CAS Number
446036-97-1
Molecular Formula
C152H252N44O42
Molecular Weight
3367.90 g/mol
Physical Form
Lyophilized Powder
Storage Guidelines
-20°C, desiccated and protected from light
Amino Acid Sequence
H-Y-(D-Ala)-DAIFTQSYRKVLAQLSARKLLQDILSR-NH2
Substitutions vs GHRH(1–29): D-Ala2, Gln8, Ala15, Leu27
Quality Assurance
Every vial. Every batch. Documented.
Our release process is built for research reproducibility — independent analytics, traceable batches and tamper-evident authentication.
>99% Purity Guaranteed
Every batch must exceed 99% purity by reverse-phase HPLC before it is released to the catalog.
3rd Party Laboratory Tested
Independent analytical labs confirm purity by HPLC and molecular identity by mass spectrometry (MS).
Batch-Tracked Serialization
Each box carries a unique 6-character code linked to its production batch and verifiable online.
Strict Research-Grade Synthesis
Solid-phase synthesis, lyophilization and sealed vialing under controlled, documented conditions.
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